Functional heterogeneity of anti-endothelial cell antibodies
نویسندگان
چکیده
منابع مشابه
Anti-endothelial cell antibodies in Behçet's disease.
OBJECTIVE Circulating antibodies that bind to human endothelial cells cultured in vitro have been detected in a variety of diseases, including Behçet's disease. In this disorder the reported prevalence of AECA has varied widely. One likely source of variability is the ELISA assay itself, in which differing conditions and reagents have been used in different reports. METHODS We have re-examine...
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Two groups of antibodies against mouse resident alveolar and peritoneal macrophages have been raised individually in rabbits by immunization with whole cell suspensions of lavaged alveolar and peritoneal macrophages. The whole antisera reacted positively with neutrophils and lymphocytes. However, upon extensive absorptions with these cells the activity became restricted to macrophages. The...
متن کاملEffects of anti-endothelial cell antibodies in leprosy and malaria.
As a result of damaging endothelial cells (ECs), Mycobacterium leprae triggers the production of antibodies (Abs). These anti-EC Abs (AECAs) can be divided into two types. The first type nonspecifically reacts with components of the cytosol (CY) and can be detected by enzyme-linked immunosorbent assay (ELISA). The second specifically reacts with the EC membrane (MB) and requires fluorescence-ac...
متن کاملAnti-endothelial cell antibodies in patients with interstitial lung diseases.
BACKGROUND Anti-endothelial cell antibodies (AECA) are circulating antibodies that bind to endothelial antigens and induce endothelial cell damage. AECA have been detected in patients with collagen vascular disease (CVD) and their presence is associated with interstitial lung disease (ILD) in cases of CVD. However, the prevalence of AECA in patients with idiopathic interstitial pneumonias (IIPs...
متن کاملEndothelial cell heterogeneity.
OBJECTIVE To review recent advances in the field of endothelial cell heterogeneity, and to apply this knowledge to an understanding of site-specific vasculopathy, including acute lung injury. DATA SOURCES AND STUDY SELECTION Published research and review articles in the English language related to endothelial cell biology and endothelial cell heterogeneity. DATA EXTRACTION AND SYNTHESIS The...
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ژورنال
عنوان ژورنال: Clinical & Experimental Immunology
سال: 2001
ISSN: 0009-9104
DOI: 10.1046/j.1365-2249.2001.01528.x